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Standard glutathione is often destroyed in the gut, while liposomal formats are designed to protect the molecule for better cellular absorption

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Drug-drug interactions are more likely to occur when drugs are metabolized by CYPs due to (1) competitive inhibition, (2) irreversible inhibition (e.g., CYP3A4 with erythromycin), and (3) nonspecific inhibition (e.g., CYP2D6 with cimetidine and CYP3A4 with azole antifungals)